Pietro Roversi

I am trying to establish novel therapeutic avenues to cure a broad spectrum of rare diseases.

Each rare disease patient potentially benefitting from the therapeutic approach I propose
carries a missense mutation in a glycoprotein gene.
The mutation impairs fold of the mutate glycoprotein but does not abrogate its function
(responsive mutation).

My idea is that modulators of Endoplasmic Reticulum glycoprotein folding Quality Control
(ERQC) and/or of Endoplasmic Reticulum Associated Degradation (ERAD) would rescue secretion,
restore function and impart therapeutic benefit.

So far, we have successfully demonstrated rescue of secretion of the Q118E mutant of human Trop-2
in mammalian cells in which the gene encoding the ERQC checkpoint (UGGT1) has been deleted.
The HsTrop-2 Q118E mutant causes Gelatinous Drop-Like Corneal Dystrophy (GDLD).
UGGT1 inhibitors may one day be active ingredients for eye-drops that would alleviate the symptoms of GDLD.

Science

On June 1st 2021 after 26 wonderful years in the UK I left Brexitland behind and started my new research-only job working at CNR IBBA in Milano (Italy).

Between September 2019 and May 2021 I held a Lectureship to teach the students
of the Leicester University Natural Sciences degree course: https://le.ac.uk/courses/natural-sciences-bsc/2020

In July 2018 I took up a three-year
LISCB/Wellcome Trust ISSF Fellowship
at Leicester University: www2.le.ac.uk/institutes/liscb/research-groups/roversi

Since 1996 I have been working as a research scientist in the UK, first at the MRC-LMB in Cambridge (1996-2003), and then at the University of Oxford (2003-2018) . In 2012-2013 I was awarded a Visiting Fellowship by the Basque Foundation of Science to work in Bilbao.

I have been Subject Tutor in Biochemistry at Lincoln College, Oxford, 2008-2013.

ORCID: 0000-0001-9280-9437
Google Scholar: Profile
Research Gate: Pietro Roversi
Scopus Author ID: 6603671618
WoS Researcher ID: F-8925-2011
Linkedin: Pietro Roversi
Twitter: @pietro1968

orcid.org/0000-0001-9280-9437

In summer 2018 I published my latest book of poetry: "Tirare l'acqua".
My previous book of poetry I pinguini dei tropici was published with Arcipelago Itaca (Òsimo) in the autumn of 2017:
www.ibs.it/pinguini-dei-tropici-libro-pietro-roversi/e/9788899429270?inventoryId=90531890
Around the same time I also published my previous book:

Fratellanza (Oèdipus Edizioni, 2017) is out!
Find it on IBS:
https://www.ibs.it/fratellanza-libro-pietro-roversi/e/9788873412595?inventoryId=87039774

In the summer of 2014 I won the first prize in the Farapoesia poetry competition Insanamente 2014:
http://farapoesia.blogspot.co.uk/2014/07/vincitori-del-concorso-in-sana-mente.html

In the spring of 2014, my second book of poetry, Vamosaver, was published by Gattomerlino Superstripes in Rome, Italy:
www.ibs.it/vamosaver-libro-pietro-roversi/e/9788866830245

My first book of poetry, Una Crisi Creativa, was published in Italy in 2010:
www.ibs.it/crisi-creativa-libro-pietro-roversi/e/9788896020524

Other poems of mine have appeared on poetry blogs and websites online:

http://giocattoliblog.wordpress.com/2013/01/17/pietro-roversi-tirare-lacqua/

http://www.rivistailmonteanalogo.it/n122010/roversi_n122010.html

http://edizionineve.wordpress.com/2011/07/30/luglio-2011-numero-6/

http://atelierpoesia.blogspot.com.es/2012/05/pietro-roversi-due-poesie.html

http://vibrisse.wordpress.com/2013/08/24/lodi-del-corpo-maschile-i-pompieri/

One can read much of my unpublished poetry on the webpage:

http://pietroroversi.scrivere.info/